Speakers

Session 1: Immune dysregulation as a primary mechanism of early neurotoxicity – relevance to disease (Thursday, 9:00-10:00)
Speakers and Titles:
Jason Cannon (USA, chair): Interactions between neuroinflammation and mitophagy in Parkinson’s disease models
Barbara Viviani (Italy): Role of IL-1 in neurotoxic signaling in the developing hippocampus
Kelley T. Patten (USA): Chronic Exposure to Real-Time Traffic Related Air Pollution Increases Neuroinflammation and Promotes AD-Relevant Neuropathology in TgF344-AD rats

Session 2: Bridging Across Levels of Analysis to Advance Neurotoxic Risk Determination: Toxicology for the Second Fifth of the 21st Century (CAAT Europe-sponsored session) (Monday, 13:30-16:00)
Speakers and Titles:
Edward D. Levin (USA, chair): Zebrafish models of neurobehavioral toxicity
Marcel Leist (Germany): Human cell-based methods to assess toxicity to the developing and adult nervous systems
Michael Aschner (USA): C. elegans in toxicology studies: Does it have a predictive value?
Per Eriksson (Sweden): The use of the neonatal animal model to predict developmental neurotoxicity of POPs, pesticides, pharmaceuticals and ionizing radiation
Andréa Aguiar (USA): Novel methods for determining neurodevelopmental risk in human infants

Session 3: Next generation in vitro neurotoxicity testing: human induced pluripotent stem cell derived neuronal models (NeuCyte-sponsored session) (Tuesday, 11:00-12:30)
Speakers and Titles:
Anke M. Tukker (The Netherlands, chair): Towards animal free in vitro neurotoxicity testing: hiPSC-derived neuronal co-cultures
Aaron B. Bowman (USA, chair): Human subject-derived stem cell models for genetic-risk and neural-lineage specific assessment of vulnerability to environmentally relevant toxicants
Stefan Schildknecht (Germany): Disease-relevant glia neuron interactions in cultures derived from human iPSC and neuronal precursor cells
Danial Haag (USA): Functional Characterization of Neural Network Activity in Human iPSC-Derived Neuron/Glial Co-Cultures for In Vitro Neurotoxicity Assessment

Session 4: In vitro and other alternative methods for improving the regulatory assessment of developmental neurotoxicity (Monday, 8:30-10:00)
Speakers and Titles:
M. Sachana (France): International regulatory efforts for improved developmental neurotoxicity testing
Anna Price (Italy, chair): Mechanistic approach applied to evaluation of developmental neurotoxicity (DNT) induced by an exposure to chemical mixture
Ellen Fritsche (Germany, chair): An in vitro testing battery for the assessment of developmental neurotoxicants
Timothy Shafer (USA): Applying data from in vitro DNT approaches to real-world regulatory decision-making

Session 5: Integrating human and animal studies to develop mechanistically based biomarkers of neurotoxicity: A case study of occupational chlorpyrifos exposure (Thursday, 10:30-11:30)
Speakers and Titles:
Diane S. Rohlman (USA, chair): Occupational Pesticide Exposure Among Egyptian Adolescents: Changes Over Time
Pamela J. Lein (USA): Preclinical model of chlorpyrifos exposures and effects documented in Egyptian pesticide applicators
Fayssal Farahat (Egypt/ Saudi Arabia): Quantitative risk assessment and effectiveness of protective clothing on reducing chlorpyrifos exposure among pesticide applicators in Egypt

Session 6: Exposure paradigms for psychoactive substances; duration and times of in vitro and in vivo neurotoxicity testing (Tuesday, 8:30-10:30)
Speakers and Titles:
Michael Baumann (USA, chair): Pharmacological characterization of newly-emerging synthetic cannabinoid receptor agonists (SCRAs) found in the recreational drug marketplace
Anne Zwartsen (The Netherlands, chair): Is the decrease in in vitro neuronal activity reversible following acute and prolonged exposure to new psychoactive substances (NPS)?
James O’Callaghan (USA): Body temperature and exogenous stress hormone are major modulators of substituted amphetamine neurotoxicity and neuroinflammation
Giulia Costa (Italy): Role of age, caffeine consumption, gender and strain in the neuroinflammatory and neurotoxic effect of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)
Ulla Havemann-Reinecke (Germany): Psychosocial stress: acute and chronic effects of cannabinoids

Session 7: Compounds’ modes-of-action (MoA) causing developmental neurotoxicity (DNT) can be used for informing adverse outcome pathways (AOPs) (Wednesday, 8:30-10:00)
Chairs:
Ellen Fritsche, Germany
Anna Price, Italy
Speakers and Titles:
Tanja Waldmann (Germany): Changes in the epigenetic set-up of neuronal differentiating cells as a possible MoA of DNT drugs
Stefan Masjosthusmann (Germany): MoA analysis in human and rodent NPC: examples of arsenite and valproic acid
Helena Hogberg (USA): Rotenone is causing ROS-dependent DNT in a human 3D brain model
Oddvar Myhre (Norway): Environmental toxicant mixtures as risk factor for neurodevelopmental disorders based on epidemiological and experimental studies

Session 8: Systems neurotoxicology: From in vivo towards predictive in vitro models (Thursday, 11:30-12:30)
Speakers and Titles:
Harm J Heusinkveld (The Netherlands, chair): Integrated neurotoxicity testing in vitro
Roel PF Schins (Germany): Neurotoxicity studies of engineered nanomaterials: the added value of in vivo studies
David M. Reif (USA): The power of data integration for systems neurotoxicology

Session 9: Use of imaging data for risk assessment: Updates, challenges and future perspectives (Monday, 16:30-18:00)
Speakers and Titles:
David C. Bellinger (USA): The Role of Neuroimaging in Epidemiological Studies of Neurotoxicity
Ulrike Dydak (USA): The potential and limitations of MRI in risk assessment of metal toxicity
Christoph van Thriel (Germany): Neurophysiological methods in neuroscience and neurotoxicology – Can they be used in risk assessment?
Roberto Lucchini (USA/ Italy, chair): Neuritic plaques detected in a series of World Trade Center responders with cognitive impairment: An Amyloid PET/MRI Study

Session 10: Hot Topics in Neurotoxicology (Wednesday, 10:30-12:00)
Speakers and Titles:
Gerhard Winneke (Germany): „Gender or sex? Lessons learned from developmental neuroendocrine toxicology”
Niu Qiao (China): „Interaction of Both Aluminum Exposure and ApoEε4 Gene on Cognitive Functions and ApoER2 Protein Expression in Al-exposed Workers”
Fang Liu (USA): „Application of microRNA profiling to understand sevoflurane-induced adverse effects on the developing brain”
Laila Abdullah (USA): „Targeting anti-aging sirtuin-1 with nicotinamide riboside improves brain bioenergetics and reduces neuroinflammation in a mouse model of Gulf War Illness”
Tamara Tal (USA): „Establishing a link between microbiota and the aryl hydrocarbon receptor system in zebrafish neurobehavioral development”
Henri Schroeder (France): „Developmental neurotoxicity of perinatal exposure to HexaBromoCycloDoDecane with regards to its impact on epigenetics and neuroinflammation assessed in cerebellum”

ENDpoiNTs Session: Novel Testing Strategies for Endocrine Disruptors linked to Developmental Neurotoxicity (Tuesday, 13:30-15:00)
Pim Leonhards (The Netherlands, chair)
Speakers and Titles:
Joelle Ruegg (Sweden, chair):
The ENDpoiNTs project – Novel Testing Strategies for Endocrine Disruptors linked to Developmental Neurotoxicity
Katharina Koch (Germany): ENDpoiNTs – developing an in vitro testing battery to screen for endocrine disruptor (ED) induced developmental neurotoxicity (DNT)
Remco H.S Westerink (The Netherlands): Functional endpoints in multicellular in vitro models to assess developmental neurotoxicity induced by Endocrine Disruptive Compounds (EDCs)
Jessica Legradi (The Netherlands): A novel approach to identify neurotoxic modes of action
Walter Lichtensteiger (Switzerland): Sex-Dependent Effects of Endocrine Active Chemicals on Genes Regulating Interneuron Development in Hippocampus. Possible Role of microRNA
Nicola Caporale (Italy): From cohorts to organoids: Endocrine disruption in human neurodevelopmental models